Bills Spring 2021 Schedule
| Details | Date | Time | Opponent | Score | Location |
| April | |||||
| Box Score | Sat, 4/17/21 | 2:00 pm | PAC-9 | L 38 - 13 | Lighthouse Field |
| Box Score | Sat, 4/24/21 | 11:00 am | Eagles | W 19 - 27 | Lighthouse Field |
| May | |||||
| Box Score | Sat, 5/8/21 | 12:30 pm | @ Broncos | W 62 - 0 | |
| Box Score | Sat, 5/15/21 | 2:00 pm | Seahawks | L 40 - 13 | Lighthouse Field |
| Box Score | Sat, 5/22/21 | —:— — | Chargers | W 12 - 54 | Lighthouse Field |
| June | |||||
| Box Score | Sat, 6/5/21 | 9:45 am | Steelers | L 50 - 19 | |
| Box Score | Sat, 6/5/21 | 11:45 am | Colts | L 38 - 26 | |
| Box Score | Sat, 6/12/21 | 11:00 am | @ Eagles | W 32 - 26 | |
